LATE-BREAKING ABSTRACT: The metalloproteinase ADAM8 promotes acute and chronic lung inflammation

Acute respiratory distress syndrome and pulmonary fibrosis are progressive inflammatory lung diseases with high mortality rates. The disintegrin and metalloproteinase (ADAM) 8, expressed by leukocytes, endothelial cells and epithelial cells is upregulated in lungs during malignant and inflammatory processes. ADAM8 mediates the release of soluble factors by proteolytic cleavage as well as adhesive cell interactions and migratory processes. Here...