Daniela Dreymueller
Saarland University
Matrix metalloproteinaseChemokineCell migrationPathologyCellMolecular biologyCell adhesion moleculeProinflammatory cytokineTumor necrosis factor alphaProteasesChemistryImmunologyInflammationDisintegrinADAM10ADAM8Lung injuryCancer researchMetalloproteinaseMedicineBiologyCell biology
36Publications
16H-index
834Citations
Publications 35
Newest
#1Aaron Babendreyer (RWTH Aachen University)H-Index: 8
#2Lisa Molls (RWTH Aachen University)H-Index: 2
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 11 authors...
Abstract Reduced shear stress resulting from disturbed blood flow can impair endothelial integrity and drive the development of vascular inflammatory lesions. Metalloproteinases of the ADAM family have been implicated in the regulation of cell survival and inflammatory responses. Here we investigate the mechanism and function of ADAM15 upregulation in primary flow cultured endothelial cells. Transcriptomic analysis indicated that within the ADAM family ADAM15 mRNA is most prominently upregulated...
10 CitationsSource
#2E. van der VorstH-Index: 1
Last. E. BiessenH-Index: 5
view all 13 authors...
Source
#1Daniel Schick (RWTH Aachen University)H-Index: 2
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Daniela Dreymueller (Saarland University)H-Index: 16
view all 13 authors...
Abstract Background and aims Members of the family of a disintegrin and metalloproteinases (ADAMs) and their substrates have been previously shown to modulate the inflammatory response in cardiac diseases, but studies investigating the relevance of ADAM8 are still rare. Our aim is to provide evidence for the inflammatory dysregulation of ADAM8 in vascular diseases and its association with disease severity. Methods Western-type diet fed Apoe−/− and Ldlr−/− mice and artery ligation served as murin...
6 CitationsSource
#1Pardes Habib (RWTH Aachen University)H-Index: 11
#2Daniela Dreymueller (RWTH Aachen University)H-Index: 16
Last. Cordian Beyer (RWTH Aachen University)H-Index: 55
view all 9 authors...
Abstract Estrogens modulate the immune system and possess anti-inflammatory properties. In line, immune cells express a variety of estrogen receptors (ER) including ER-alpha and -beta. In the present study, we examined the influence of 17beta-estradiol (E2) serum concentrations on blood leukocyte composition and their ex vivo polarization/activation status by FACS analysis in sub-fertile human females under controlled ovarian stimulation (COS). Using a set of cell-type and polarization-specific ...
16 CitationsSource
#1Bernhard Josef Rüther (RWTH Aachen University)H-Index: 2
#2Miriam Scheld (RWTH Aachen University)H-Index: 7
Last. Markus Kipp (LMU: Ludwig Maximilian University of Munich)H-Index: 4
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Brain-intrinsic degenerative cascades are a proposed factor driving inflammatory lesion formation in multiple sclerosis (MS) patients. We recently described a model combining noninflammatory cytodegeneration (via cuprizone) with the classic active experimental autoimmune encephalomyelitis (Cup/EAE model), which exhibits inflammatory forebrain lesions. Here, we describe the histopathological characteristics and progression of these Cup/EAE lesions. We show that inflammatory lesions develop at var...
38 CitationsSource
#1Daniela Dreymueller (RWTH Aachen University)H-Index: 16
#2Jessica Pruessmeyer (RWTH Aachen University)H-Index: 14
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 9 authors...
Alveolar leukocyte recruitment is a hallmark of acute lung inflammation and involves transmigration of leukocytes through endothelial and epithelial layers. The disintegrin and metalloproteinase (ADAM) 8 is expressed on human isolated leukocytic cells and can be further upregulated on cultured endothelial and epithelial cells by proinflammatory cytokines. By shRNA mediated knockdown we show that leukocytic ADAM8 is required on monocytic THP-1 cells for chemokine-induced chemotaxis as well as tra...
15 CitationsSource
#1Daniela Dreymueller (RWTH Aachen University)H-Index: 16
#2Andreas Ludwig (RWTH Aachen University)H-Index: 63
AbstractProteases of the disintegrin and metalloproteinase (ADAM) family mediate the proteolytic shedding of various surface molecules including cytokine precursors, adhesion molecules, growth factors, and receptors. Within the vasculature ADAM10 and ADAM17 regulate endothelial permeability, transendothelial leukocyte migration, and the adhesion of leukocytes and platelets. In vivo studies show that both proteases are implicated in several inflammatory pathologies, for example, edema formation, ...
18 CitationsSource
#1Aaron Babendreyer (RWTH Aachen University)H-Index: 8
#2Lisa Molls (RWTH Aachen University)H-Index: 2
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 5 authors...
Flow conditions critically regulate endothelial cell functions in the vasculature. Reduced shear stress resulting from disturbed blood flow can drive the development of vascular inflammatory lesions. On endothelial cells, the transmembrane chemokine CX3CL1/fractalkine promotes vascular inflammation by functioning as a surface-expressed adhesion molecule and by becoming released as soluble chemoattractant for monocytic cells expressing the receptor CX3CR1. Here, we report that endothelial cells f...
9 CitationsSource
#1Andrea Koenen (RWTH Aachen University)H-Index: 2
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Daniela Dreymueller (RWTH Aachen University)H-Index: 16
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The CXC-chemokine receptor 6 (CXCR6) is a class A GTP-binding protein-coupled receptor (GPCRs) that mediates adhesion of leukocytes by interacting with the transmembrane cell surface-expressed chemokine ligand 16 (CXCL16), and also regulates leukocyte migration by interacting with the soluble shed variant of CXCL16. In contrast to virtually all other chemokine receptors with chemotactic activity, CXCR6 carries a DRF motif instead of the typical DRY motif as a key element in receptor activation a...
13 CitationsSource
#1Daniela Dreymueller (RWTH Aachen University)H-Index: 16
#2Kosta Theodorou (UM: Maastricht University)H-Index: 6
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 4 authors...
Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer...
18 CitationsSource