The Genetic Architecture of Major Depressive Disorder in Han Chinese Women

Importance

Despite the moderate, well-demonstrated heritability of major depressive disorder (MDD), there has been limited success in identifying replicable genetic risk loci, suggesting a complex genetic architecture. Research is needed to quantify the relative contribution of classes of genetic variation across the genome to inform future genetic studies of MDD.

Objectives

To apply aggregate genetic risk methods to clarify...