Importance null Suicide and suicide attempts are persistent and increasing public health problems. Observational studies and meta-analyses of randomized clinical trials have suggested that lithium may prevent suicide in patients with bipolar disorder or depression. null Objective null To assess whether lithium augmentation of usual care reduces the rate of repeated episodes of suicide-related events (repeated suicide attempts, interrupted attempts, hospitalizations to prevent suicide, and deaths...
#2Louise Sharpe(USYD: University of Sydney)H-Index: 66
Last. Ben Colagiuri(USYD: University of Sydney)H-Index: 25
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Importance null Single-blind placebo run-in (PRI) periods are common in randomized clinical trials (RCTs) of treatment for depression. They aim to increase sensitivity to detect drug effects; however, the association of PRI periods with study outcomes remains unclear. This is concerning given the costs of PRI periods to patients and investigators. null Objective null To examine the association of the use of PRI periods with the placebo response, drug response, and drug-placebo difference among R...
Importance null Prenatal cannabis use continues to increase, yet studies of the demographic, psychiatric, and medical characteristics associated with cannabis use in pregnancy are limited by size and use of self-report, and often do not consider cannabis use disorder (CUD) or concomitant substance use disorders (SUDs). Understanding the factors associated with CUD in pregnancy is paramount for designing targeted interventions. null Objective null To examine the prevalence of co-occurring psychia...
Importance null A substantial proportion of the 40 million people in the US who present to emergency departments (EDs) each year after traumatic events develop posttraumatic stress disorder (PTSD) or major depressive episode (MDE). Accurately identifying patients at high risk in the ED would facilitate the targeting of preventive interventions. null Objectives null To develop and validate a prediction tool based on ED reports after a motor vehicle collision to predict PTSD or MDE 3 months later....
Last. Francesca Solmi(UCL: University College London)H-Index: 17
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Importance null People with anorexia nervosa often experience difficulties regulating their emotions. There is no longitudinal evidence as to whether these differences are already present in childhood or when they begin to emerge. null Objective null To investigate the association between emotion regulation trajectories from 3 to 7 years of age and symptoms of anorexia nervosa and atypical anorexia nervosa in adolescence. null Design, setting, and participants null This cohort study included all...
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