Inherent variability of cancer-specific aneuploidy generates metastases
Abstract
The genetic basis of metastasis is still unclear because metastases carry individual karyotypes and phenotypes, rather than consistent mutations, and are rare compared to conventional mutation. There is however correlative evidence that metastasis depends on cancer-specific aneuploidy, and that metastases are karyotypically related to parental cancers. Accordingly we propose that metastasis is a speciation event. This theory holds that...
Paper Details
Title
Inherent variability of cancer-specific aneuploidy generates metastases
Published Date
Dec 1, 2016
Journal
Volume
9
Issue
1
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