Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE
Abstract
Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation-induced deaminase to initiate class switching in B cells. Differential regulation of Iε and Iγ1 transcription in response to interleukin 4 (IL-4), hence class switching to IgE and IgG1, is not fully understood. In this study, we combine novel mouse reporters and single-cell RNA sequencing to reveal the heterogeneity...
Paper Details
Title
Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE
Published Date
Dec 19, 2016
Volume
214
Issue
1
Pages
183 - 196
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