Original paper
CCT complex restricts neuropathogenic protein aggregation via autophagy
Abstract
Aberrant protein aggregation is controlled by various chaperones, including CCT (chaperonin containing TCP-1)/TCP-1/TRiC. Mutated CCT4/5 subunits cause sensory neuropathy and CCT5 expression is decreased in Alzheimer’s disease. Here, we show that CCT integrity is essential for autophagosome degradation in cells or Drosophila and this phenomenon is orchestrated by the actin cytoskeleton. When autophagic flux is reduced by compromise of individual...
Paper Details
Title
CCT complex restricts neuropathogenic protein aggregation via autophagy
Published Date
Dec 8, 2016
Journal
Volume
7
Issue
1