Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity
Abstract
2,4-Dichlorophenol (2,4-DCP) is an environmental pollutant exhibiting a wide spectrum of toxic effects. We investigated the toxic effects and potential mechanisms underlying 2,4-DCP-induced hepatotoxicity. In vitro, 2,4-DCP caused hepatotoxicity manifested by a decrease in cell viability and inhibition of colony formation. Bip and CHOP expression was up-regulated at the mRNA and protein levels. Moreover, 2,4-DCP induced eIF2α phosphorylation and...
Paper Details
Title
Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity
Published Date
Jan 1, 2016
Volume
41
Issue
6
Pages
745 - 756
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