Pulse wave velocity

Kidney disease

Aorta

Risk factor

Mean arterial pressure

Cardiology

Dialysis

Blood pressure

Internal medicine

Heart rate

Medicine

Arterial stiffness

Cohort

Hypertension

Aortic stiffness, a cardiovascular risk factor, depends on the operating mean arterial pressure (MAP). The impact of aortic stiffness on cardiovascular outcomes is proposed to be mediated by the attenuation or the reversal of the arterial stiffness gradient. We hypothesized that arterial stiffness gradient is less influenced by changes in MAP. We aimed to study the relationship between MAP and aortic stiffness, brachial stiffness, and arterial stiffness gradient. In a cross-sectional study of a dialysis cohort (group A, n=304) and a cohort of hypertensive or kidney transplant recipient with an estimated glomerular filtration rate of &gt;45 mL/min/1.73 m 2 (group B, n=114), we assessed aortic and brachial stiffness by measuring carotid–femoral and carotid–radial pulse wave velocities (PWV). We used aortic–brachial PWV ratio as a measure of arterial stiffness gradient. Although there was a positive relationship between MAP and carotid–femoral PWV ( R 2 =0.10 and 0.08; P &lt;0.001 and P =0.003) and MAP and carot...

Aortic–Brachial Pulse Wave Velocity Ratio