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#1Chengxin Zhang (Anhui Medical University)
#2Kaiyuan Niu (QMUL: Queen Mary University of London)
Last. Zhaolin Chen (USTC: University of Science and Technology of China)
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Increasing evidence has suggested that noncoding RNAs (ncRNAs) have vital roles in cardiovascular tissue homeostasis and diseases. As a main subgroup of ncRNAs, long ncRNAs (lncRNAs) have been reported to play important roles in lipid metabolism, inflammation, vascular injury, and angiogenesis. They have also been implicated in many human diseases including atherosclerosis, arterial remodeling, hypertension, myocardial injury, cardiac remodeling, and heart failure. Importantly, it was reported t...
#1Spoorthy Kulkarni (Cambridge University Hospitals NHS Foundation Trust)H-Index: 3
#2Anna F. DominiczakH-Index: 114
Last. Ian B. Wilkinson (University of Cambridge)H-Index: 29
view all 11 authors...
#1Daigoro Hirohama (UTokyo: University of Tokyo)H-Index: 11
#2Mitsuhiro Nishimoto (UTokyo: University of Tokyo)H-Index: 8
Last. Toshiro Fujita (UTokyo: University of Tokyo)H-Index: 123
view all 9 authors...
The progression of diabetic kidney disease (DKD), a leading cause of end-stage kidney disease, involves mineralocorticoid receptor (MR) activation. We previously identified crosstalk between the small guanosine triphosphatase (GTPase) RAS-related C3 botulinus toxin substrate 1 (Rac1) and MR, but the role of Rac1-MR pathway activation in the progression of DKD is not clear. We performed uninephrectomy on type 2 diabetic mouse models, db/db (UNx-high salt [HS] db/db), and their lean control, db/m ...
#1Kunihiko Aizawa (University of Exeter)H-Index: 9
#2Francesco Casanova (University of Exeter)H-Index: 11
Last. Alun D. Hughes (UCL: University College London)H-Index: 84
view all 14 authors...
The parameters derived from reservoir-excess pressure analysis have prognostic utility in several populations. However, evidence in type 2 diabetes (T2DM) remains scarce. We determined if these parameters were associated with T2DM and whether they would predict cardiovascular events in individuals with T2DM. We studied 306 people with T2DM with cardiovascular disease (CVD; DMCVD, 70.4±7.8 years), 348 people with T2DM but without CVD (diabetes mellitus, 67.7±8.4 years), and 178 people without T2D...
#1Zhennan Lin (Peking Union Medical College)
#2Xinyan Wang (Peking Union Medical College)H-Index: 3
Last. Jianfeng Huang (Peking Union Medical College)H-Index: 35
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Previous studies revealed that fine particulate matter (PM2.5) exposure adversely affected blood pressure (BP), but factors that might attenuate this association were still unclear. Using a multicenter panel study among 277 hypertensive participants with intermediate-to-high risk of cardiovascular disease from 4 cities in China, we aimed to explore whether BP control status and antihypertensive medications were potential modifying factors. Each participant carried personal-portable monitors to r...
#1Qinqin Li (Southern Medical University)H-Index: 1
#2Rui Li (Anhui Medical University)
Last. Xianhui Qin (Southern Medical University)H-Index: 25
view all 11 authors...
The association between occupational physical activity (OPA) and the risk of hypertension remains uncertain. We aimed to examine the prospective relations of OPA and new-onset hypertension among Chinese males and females. A total of 9350 adults who were free of hypertension at baseline were enrolled from the CHNS study (China Health and Nutrition Survey). Data on OPA were obtained by using self-reported questionnaires and calculated as metabolic equivalent task (MET)-hours per week. MET-hours pe...
#1Karolina Wartolowska (University of Oxford)H-Index: 19
Last. A Webb
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Small vessel disease and related stroke and dementia risks are linked to aging and hypertension, but it is unclear whether the pulsatile or steady blood pressure (BP) component is more important for the development of macrostructural hyperintensities and microstructural white matter damage. This was a cross-sectional analysis of the UK Biobank cohort study of community-based adults from 22 UK centers. Linear associations were determined between neuroimaging markers (white matter hyperintensity [...
#1Janis M. Dionne (UBC: University of British Columbia)H-Index: 18
#2Shuai Jiang (Johns Hopkins University)H-Index: 3
Last. Joshua Samuels (University of Texas Health Science Center at Houston)H-Index: 28
view all 8 authors...
Consensus blood pressure guidelines vary in their recommended ambulatory blood pressure targets for children with chronic kidney disease (CKD) because of limited research in this area. We analyzed longitudinal ambulatory blood pressure monitoring data from 679 children with moderate CKD enrolled in the observational CKiD (Chronic Kidney Disease in Children) cohort by time-varying mean arterial pressure (MAP) percentile categories based on the highest wake or sleep MAP percentile. Analyses were s...
#1Louise Newman (Trinity College, Dublin)H-Index: 5
#2John O'Connor (Trinity College, Dublin)H-Index: 8
Last. Rose Anne Kenny (Trinity College, Dublin)H-Index: 91
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The cerebrovascular effects of supine hypertension (SH) are still poorly understood. With aging and atherosclerosis of the vascular system, it is not uncommon for SH and non-neurogenic orthostatic hypotension to co-occur. Given evidence for end organ damage and more extreme cerebral dysfunction in those with SH-orthostatic hypotension, we hypothesized that SH would be associated with impaired cerebral autoregulation. The aim of this study was to characterize the cerebrovascular response to ortho...
#1Lucie S. Meyer (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Laura Handgriff (LMU: Ludwig Maximilian University of Munich)H-Index: 2
Last. Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
view all 13 authors...
Unilateral forms of primary aldosteronism are usually surgically treated to remove the source of aldosterone excess. After adrenalectomy, aldosteronism persists in some patients indicating abnormal aldosterone production from the unresected gland. Our objective was to investigate histopathology, genotype, and postsurgical outcomes in a 3-year prospective cohort of surgically treated patients for primary aldosteronism (from 2016 to 2018). The cohort comprised 60 consecutively operated patients ca...
Top fields of study
Angiotensin II
Diabetes mellitus
Blood pressure