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Original paper

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

Volume: 113, Issue: 49, Pages: 14043 - 14048
Published: Nov 21, 2016
Abstract
Significance Mechanical interactions between cells and the ECM critically regulate cell function, including growth and migration. By measuring forces exerted by breast tumor cells embedded within collagen matrices, we reveal a positive mechanical cross-talk between the cell and ECM: cells pulling onto collagen fibers align and stiffen the matrices, and stiffer collagen matrices promote greater cell force generation. Our work highlights the...
Paper Details
Title
Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs
Published Date
Nov 21, 2016
Volume
113
Issue
49
Pages
14043 - 14048
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