Testicular Diffuse Large B-Cell Lymphoma of Activated B-Cel Subtype Is Frequently Associated with Clonally Related Non-Follicular Small B-Cell Lymphoma in the Bone Marrow.

Diffuse large B-cell lymphoma (DLBCL) of the testis is an uncommon non-Hodgkin’ s lymphoma. It accounts for 1 % of all lymphomas but represents the most frequent testicular tumor in men over the age of 60. Most patients have localized disease but involvement of other extranodal sites is not uncommon. Of interest, an activated B-cell like (ACT) phenotype has been reported in the majority of testicular DLBCL and even those cases with a germinal...