Endoscopic ultrasonography in chronic asymptomatic pancreatic hyperenzymemia: The more we see, the less we know.

Published on Nov 1, 2016in Digestive and Liver Disease3.57
· DOI :10.1016/J.DLD.2016.11.009
Luca Frulloni58
Estimated H-index: 58
(University of Verona),
Antonio Amodio13
Estimated H-index: 13
(University of Verona)
Source
Abstract
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References17
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#1Milena Di Leo (UniSR: Vita-Salute San Raffaele University)H-Index: 17
#2Maria Chiara Petrone (UniSR: Vita-Salute San Raffaele University)H-Index: 19
Last. Alberto Mariani (UniSR: Vita-Salute San Raffaele University)H-Index: 27
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Background Magnetic resonance cholangio-pancreatography (MRCP) findings in people with chronic asymptomatic pancreatic hyperenzymemia (CAPH) have shifted the hypothesis that CAPH is always non-pathological. However, there have been no studies including both secretin-MRCP (S-MRCP) and endoscopic ultrasonography (EUS) to examine the pancreatic morphology in these subjects. Aim To prospectively assess the diagnostic approach for CAPH using both pancreatic EUS and S-MRCP. Methods In a case-control p...
8 CitationsSource
RESULTS: Data relative to 160 subjects (94 males, 66 females, age 49.6 ± 13.6 years) were analyzed. In all, 51 (32 % ) subjects had hyperamylasemia, 9 (6 % ) hyperlipasemia, and 100 (62 % ) an increase in both enzyme levels. The time between the fi rst increased dosage of serum pancreatic enzymes and our observation was 3.3 ± 3.9 years (range: 1 - 15). Familial pancreatic hyperenzymemia was observed in 26 out of 133 subjects (19.5 % ). Anatomic abnormalities of the pancreatic duct system at s-MR...
30 CitationsSource
#1Erwin J M van Geenen (VUmc: VU University Medical Center)H-Index: 5
#2Mark M. SmitsH-Index: 22
Last. Chris J. J. MulderH-Index: 77
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OBJECTIVES:Smokers are at risk for pancreatic cancer (PC) and other pancreatic diseases. Cigarette smoking also aggravates the risk of PC in patients with hereditary and chronic pancreatitis (CP) and results in a higher incidence of acute pancreatitis and relapses in CP. Both PC and CP are character
50 CitationsSource
#2Piero BoraschiH-Index: 22
Last. Fabio FalaschiH-Index: 24
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Abstract Purpose To assess the diagnostic value of secretin-stimulated MRCP (SS-MRCP) compared with conventional MRCP in asymptomatic patients with mild elevations of pancreatic enzymes. Materials and methods Eighty asymptomatic patients with pancreatic hyperenzymemia underwent MR imaging at 1.5 T-device (Signa EXCITE, GE Healthcare). After the acquisition of axial T1w,T2w sequences, and conventional MRCP, SS-MRCP was performed using a single-slice coronal breath-hold, thick-slab, SSFSE T2w sequ...
20 CitationsSource
Objective. Prospectively to evaluate patients with chronic asymptomatic pancreatic hyperenzymemia in order to identify possible pancreatic and non-pancreatic diseases. Material and methods. Seventy-five asymptomatic subjects with long-standing pancreatic hyperenzymemia (45 M, 30 F; mean age±SD 51.5±16.0 years, range 19–78 years, mean duration±SD of pancreatic hyperenzymemia 14.7±7.0 months, range 7–34 months) and normal ultrasonographic evaluation were included in this study. The subjects enroll...
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#1Pier Alberto Testoni (UniSR: Vita-Salute San Raffaele University)H-Index: 39
#2Alberto MarianiH-Index: 6
Last. Enzo MasciH-Index: 27
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Pancreatic Ductal Abnormalities Documented by Secretin-Enhanced MRCP in Asymptomatic Subjects With Chronic Pancreatic Hyperenzymemia
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#1Marc F. CatalanoH-Index: 37
#2Anand V. SahaiH-Index: 24
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Background EUS is increasingly used in the diagnosis of chronic pancreatitis (CP). A number of publications in this field have used different EUS terminology, features, and criteria for CP, making it difficult to reproduce their findings and apply them in clinical practice. Moreover, traditional criteria such as the Cambridge classification for CP are arguably outdated and have lost their relevance. Objective Our purpose was to establish consensus-based criteria for EUS features of CP. Design Co...
460 CitationsSource
Background & Aims: Benign pancreatic hyperenzymemia is a newly identified syndrome that is characterized by a chronic increase of serum pancreatic enzymes in the absence of pancreatic disease. When checked at intervals of months or years, the enzyme levels show considerable variation from one test to another, and enzyme normalization is sometimes seen. The purpose of this study was to determine whether these variations can occur on a day-to-day basis. Methods: Forty-two subjects with benign panc...
32 CitationsSource
#1Lucio Gullo (UNIBO: University of Bologna)H-Index: 29
#2Laura LucrezioH-Index: 5
Last. Marina MiglioriH-Index: 19
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Benign pancreatic hyperenzymemia is a newly identified syndrome characterized by an abnormal increase in serum pancreatic enzymes in the absence of pancreatic disease. The hyperenzymemia can occur sporadically or in a familial form, and all of the pancreatic enzymes show elevations. Although the condition is persistent, the enzyme elevations fluctuate considerably, even temporarily returning to normal levels at times. In this review the main characteristics of this syndrome are described.
8 Citations
#1Luca FrulloniH-Index: 58
#2Franca PatriziH-Index: 1
Last. Giorgio CavalliniH-Index: 52
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An increase in the serum concentration of pancreatic enzymes (amylase and lipase) is commonly an expression of inflammatory or neoplastic pancreatic disease. However, an elevation of pancreatic enzymes, generally mild, may be a non-specific phenomenon without any clinical implication. The large spreading of the serum pancreatic enzymes dosage in clinical practice, particularly in emergency rooms, results in a large number of patients with elevated amylase and/or lipase serum levels without clini...
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#1Wataru Gonoi (UTokyo: University of Tokyo)H-Index: 17
#2Takana Yamakawa Hayashi (UTokyo: University of Tokyo)H-Index: 2
Last. Osamu Abe (UTokyo: University of Tokyo)H-Index: 67
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Purpose Elucidating the association between pancreatic ductal anomalies and chronic asymptomatic pancreatic hyperenzymemia using magnetic resonance cholangiopancreatography.
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#1Antonio AmodioH-Index: 13
#2Giulia De MarchiH-Index: 6
Last. Luca FrulloniH-Index: 58
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OBJECTIVES: Chronic asymptomatic pancreatic hyperenzymemia (CAPH) was described as a benign disease. However, we already described clinically relevant findings requiring surgery or follow-up in half of the subjects. The aim of this study was to evaluate the long-term outcome of CAPH in terms of symptoms and evolution toward chronic pancreatitis. METHODS: Subjects previously enrolled in the first phase of the study (from 2005 to 2010) were reinvestigated from December 2013 to January 2017 with a ...
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#1Giuseppe Vanella (Sapienza University of Rome)H-Index: 8
Last. Gabriele CapursoH-Index: 56
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Abstract Background/Objectives Data estimating the prevalence of significant findings during the investigation of patients with Chronic Asymptomatic Pancreatic Hyperenzymemia (CAPH) are scanty and heterogeneous, and the diagnostic approach is therefore uncertain. The aim of this study was to meta-analyze pancreatic abnormalities detected at second-level imaging in patients with CAPH. Methods Pubmed database was searched until September 2018 for articles evaluating CAPH patients through MRI-Chola...
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#1Filippo AntoniniH-Index: 9
#2Giampiero MacarriH-Index: 17
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