Sphingolipids in obesity and related complications

Sphingolipids are biologically active lipids ubiquitously produced in all vertebrate cells. Aside from their role as structural components of cell membranes, sphingolipids also function as intracellular and extracellular mediators that regulate many important physiological cellular processes including cell survival, proliferation, apoptosis, differentiation, migration and immune processes. Recent studies have also indicated that disruption of...