Frontiers in Bioscience
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#1Yan Wang (Fourth Military Medical University)H-Index: 11
#2Rui-Rui Wang (Fourth Military Medical University)H-Index: 9
Last. Jun Chen (Fourth Military Medical University)H-Index: 27
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Tetrahydropalmatine (dl-THP) demonstrates an analgesic effect in animal models of neuropathic and inflammatory pain, however, the underlying mechanisms of its pharmacological action within the spinal cord remains unclear. Both P2X3 receptor and TRPV1 are associated with the development and progression of such neuropathic and inflammatory pain. Here, we found that both pre-treatment and post-treatment with dl-THP could attenuate Bee Venom (BV)-induced persistent spontaneous pain-related behaviors...
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#1Leena Sapra (AIIMS: All India Institute of Medical Sciences)H-Index: 2
#2Asha Bhardwaj (AIIMS: All India Institute of Medical Sciences)H-Index: 1
Last. Rupesh K. Srivastava (AIIMS: All India Institute of Medical Sciences)H-Index: 16
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In 2020, a novel strain of coronavirus (COVID-19) has led to a significant morbidity and mortality worldwide. As of the date of this writing, a total of 116 M cases has been diagnosed worldwide leading to 2.5 M deaths. The number of mortalities is directly correlated with the rise of innate immune cells (especially macrophages) in the lungs that secrete inflammatory cytokines (IL-1β and IL-6) leading to the development of "Cytokine Storm Syndrome" (CSS), multi-organ-failure and death. Given that...
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#1Yu-Ye Wang (PRC: China Medical University (PRC))
#2Yanzhe Wang (PRC: China Medical University (PRC))H-Index: 6
Last. Zhiyi He (PRC: China Medical University (PRC))H-Index: 10
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Circular RNAs are single-stranded RNAs which are closed by covalent bonds during splicing. Different from other RNAs, circular RNAs are well known due to their circular structure. In recent years, many researches were conducted to investigate the role of circular RNAs in multiple diseases. To better understand the structure of circular RNAs, we reviewed the biogenesis and related regulation at first. Mechanisms by which circular RNAs exert effects were summarized then. Due to the conserved and b...
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#1Andrea Pautz (University of Mainz)H-Index: 21
#2Huige Li (University of Mainz)H-Index: 64
Last. Hartmut Kleinert (University of Mainz)H-Index: 50
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Nitric oxide synthases (NOS) are the major sources of nitric oxide (NO), a small bioactive molecule involved in the regulation of many cellular processes. One of the most prominent functions of NO is regulation of vasodilatation and thereby control of blood pressure. Most important for vascular tone is NOS3. Endothelial NOS3-generated NO diffuses into the vascular smooth muscle cells, activates the soluble guanylate cyclase resulting in enhanced cGMP concentrations and smooth muscle cell relaxat...
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#1Bin-Lie Chen (STU: Shantou University)
#2Huaiming Wang (STU: Shantou University)H-Index: 1
Last. Yongming Zeng (STU: Shantou University)H-Index: 1
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Recently, Up-frameshift protein 1 (UPF1) is reported to be downregulated in various cancers and its low expression is closely correlated with poor prognosis. UPF1 is well known as a master regulator of nonsense-mediated mRNA decay (NMD), which serves as a highly conserved mRNA surveillance process protecting cells from aberrant toxic transcripts. Due to dysfunction of UPF1, NMD fails to proceed, which contributes to tumor initiation and progression. This review shows a brief summary of the aberr...
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#1Rashed Noor (Independent University, Bangladesh)H-Index: 5
#2Adiba Naz (Independent University, Bangladesh)
Last. Muntasir Billah (Kolling Institute of Medical Research)
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Cardiovascular diseases including myocardial infarctions, myocarditis, strokes, coronary artery disease, chronic granulomatous disease, atherosclerotic cardiovascular disease, etc. can be regarded as the severe health trouble round the globe. The reasons behind the heart related complications have been well chalked our so far. Interestingly, along with the non-infectious reasons, an array of bacteria, fungi, parasites and viruses is known to cause different types of heart complications. Unfortun...
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#1Reetabrita Roy (Acharya Prafulla Chandra College)
#2Pallab Chakraborty (Acharya Prafulla Chandra College)
Last. Joy Sarkar (Dinabandhu Andrews College)H-Index: 15
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Being polymorphic, deoxyribonucleic acid is worthy of raise a variety of structure like right-handed B to left-handed Z conformation. In left-handed contour of DNA consecutive nucleotides substitute between syn-arrangement and anti-arrangement, through the chain. 2D gel electrophoresis comprising d(PCpG)n of topo isomers of a plasmid inserts d(pCpG)n, in this 'n' ranges among 8 to 21, indicate the change of B-Z DNA. The high denseness of salt is required for conversion of B configuration d(CG)n ...
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#1Jahangir Iqbal (King Saud bin Abdulaziz University for Health Sciences)H-Index: 1
#2Ali Ahmed Al Qarni (King Saud bin Abdulaziz University for Health Sciences)H-Index: 2
Last. Ahmed Bakillah (King Saud bin Abdulaziz University for Health Sciences)H-Index: 1
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Intestinal and hepatic lipid metabolism plays an essential role in regulating plasma lipid levels. These lipids are mobilized on apolipoprotein B (apoB)-containing lipoproteins and their plasma homeostasis is maintained by balancing production and catabolism. Microsomal triglyceride transfer protein (MTP) which is expressed mainly in the intestine and liver plays an essential role in regulating the assembly and secretion of apoB-lipoproteins. Any imbalance in the production or clearance of lipop...
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#1Antonio Monroy-Noyola (Universidad Autónoma del Estado de Morelos)H-Index: 10
#2Damianys Almenares-López (Universidad Popular de la Chontalpa)H-Index: 3
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Some organophosphorus compounds (OPs), which are used in the manufacturing of insecticides and nerve agents, are racemic mixtures with at least one chiral center with a phosphorus atom. Acute exposure of humans to these mixtures induces the covalent modification of acetylcholinesterase (AChE) and neuropathy target esterase (NTE) and causes a cholinergic syndrome or organophosphate-induced delayed polyneuropathy syndrome (OPIDP). These irreversible neurological effects are due to the stereoselect...
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Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient sensors including AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), the insulin/insulin-like IIGF) growth factor signaling pathway (IIS), sirtuins, NFkB, and FOXO. Aging can be delayed and life-span and health-span can be e...
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