PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis
Abstract
Mitochondrial dysfunction, oxidative stress, inflammation, and metabolic reprograming are crucial contributors to hepatic injury and subsequent liver fibrosis. Poly(ADP-ribose) polymerases (PARP) and their interactions with sirtuins play an important role in regulating intermediary metabolism in this process. However, there is little research into whether PARP inhibition affects alcoholic and non-alcoholic steatohepatitis (ASH/NASH).We...
Paper Details
Title
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis
Published Date
Mar 1, 2017
Journal
Volume
66
Issue
3
Pages
589 - 600
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