Inhibition of melatonin metabolism in humans induced by chemical components from herbs and effective prediction of this risk using a computational model

Background and Purpose Herbs which are widely used as food and medicine, are involved in many physiopathological processes. Melatonin is a human hormone, synthesized and secreted by the pineal gland, with a range of biological functions. Here, we have evaluated the potential influences of components extracted from common herbs on melatonin metabolism in humans. Experimental Approach An in vivo pharmacokinetic study involving 12 healthy subjects,...