Ironing out how p53 regulates ferroptosis

Since it was first found capable of suppressing transformation by E1A and RAS oncogenes (1), and then shortly thereafter discovered to be mutationally inactivated in over half of all human tumors (2), uncovering how the TP53 tumor suppressor (hereafter p53) inhibits tumor initiation and progression has remained one of the holy grails of the cancer field. At no point in this journey has p53 been readily forthcoming about its secret...