Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer
Volume: 113, Issue: 42
Published: Sep 30, 2016
Abstract
Metastatic castration-resistant prostate cancer (CRPC) is the primary cause of prostate cancer-specific mortality. Defining new mechanisms that can predict recurrence and drive lethal CRPC is critical. Here, we demonstrate that localized high-risk prostate cancer and metastatic CRPC, but not benign prostate tissues or low/intermediate-risk prostate cancer, express high levels of nuclear Notch homolog 1, translocation-associated (Notch1) receptor...
Paper Details
Title
Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer
Published Date
Sep 30, 2016
Volume
113
Issue
42
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