sulfones

trifluoromethyl

trifluoromethylation

tengs

org chem date_57980

mode control

trifluoromethylated

sulfonylation

emergency medicine

inorg chem date_56547

oligonucleotide

trifluoromethylthiolation

arenes

fluorides

fermentation quality

embryo production

more-than-human

electroslag

Organic Letters

The first use of the NH S-trifluoromethyl sulfoximine as an ortho directing group is described for the functionalization of the aryl group bonded to the sulfur atom. Various electrophiles (halogen, carbon, oxygen, sulfur, boron, etc.) are introduced on the aromatic ring. Cyclic S-trifluoromethyl sulfoximines are synthesized either with properly chosen electrophiles or by structural adjustment of o-azido sulfoximines. Fluorinated analogues of prazosin are also prepared.

S-Trifluoromethyl Sulfoximine as a Directing Group in Ortho-Lithiation Reaction toward Structural Complexity