Faecal microbiota transplantation: a review of FMT as an alternative treatment for Clostridium difficile infection

Published on Jan 1, 2016in Bioscience Horizons
Chris Dowle1
Estimated H-index: 1
(Swansea University)
📖 Papers frequently viewed together
1 Author (Lucas Tremearne)
16 Citations
In September, the decision by Turing Pharmaceuticals to increase the price of pyrimethamine, a 62-year-old generic drug used to treat toxoplasmosis and malaria, from approximately 13.50 to 50.00 per pill resulted in a firestorm that ignited social media, led to harsh criticism by 2 Democratic presidential candidates, and was the subject of a satirical monologue by Bill Maher. Walter Palmer, the dentist who killed Cecil the lion in Zimbabwe, must have breathed a sigh of relief as he watched Tu...
10 CitationsSource
#1Giovanni Cammarota (CUA: The Catholic University of America)H-Index: 62
#2Luca Masucci (CUA: The Catholic University of America)H-Index: 23
Last. Antonio Gasbarrini (CUA: The Catholic University of America)H-Index: 104
view all 8 authors...
SummaryBackground Faecal microbiota transplantation (FMT) from healthy donors is considered an effective treatment against recurrent Clostridium difficile infection. Aim To study the effect of FMT via colonoscopy in patients with recurrent C. difficile infection compared to the standard vancomycin regimen. Methods In an open-label, randomised clinical trial, we assigned subjects with recurrent C. difficile infection to receive: FMT, short regimen of vancomycin (125 mg four times a day for 3 days...
360 CitationsSource
#1Fernanda C. LessaH-Index: 26
#2Yi Mu (CDC: Centers for Disease Control and Prevention)H-Index: 19
Last. L. Clifford McDonald (CDC: Centers for Disease Control and Prevention)H-Index: 71
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Background The magnitude and scope of Clostridium difficile infection in the United States continue to evolve. Methods In 2011, we performed active population- and laboratory-based surveillance across 10 geographic areas in the United States to identify cases of C. difficile infection (stool specimens positive for C. difficile on either toxin or molecular assay in residents ≥1 year of age). Cases were classified as community-associated or health care–associated. In a sample of cases of C. diffic...
1,825 CitationsSource
#1Neha Alang (Newport Hospital)H-Index: 2
#2Colleen R. Kelly (Brown University)H-Index: 29
Fecal microbiota transplantation (FMT) is a promising treatment for recurrent Clostridium difficile infection. We report a case of a woman successfully treated with FMT who developed new-onset obesity after receiving stool from a healthy but overweight donor. This case may stimulate further studies on the mechanisms of the nutritional-neural-microbiota axis and reports of outcomes in patients who have used nonideal donors for FMT.
273 CitationsSource
#1Thomas P. Van Boeckel (Princeton University)H-Index: 25
#2Sumanth Gandra (Center for Disease Dynamics, Economics & Policy)H-Index: 22
Last. Ramanan Laxminarayan (Princeton University)H-Index: 71
view all 7 authors...
Summary Background Antibiotic drug consumption is a major driver of antibiotic resistance. Variations in antibiotic resistance across countries are attributable, in part, to different volumes and patterns for antibiotic consumption. We aimed to assess variations in consumption to assist monitoring of the rise of resistance and development of rational-use policies and to provide a baseline for future assessment. Methods With use of sales data for retail and hospital pharmacies from the IMS Health...
1,219 CitationsSource
#1Grace C. Lee (University of Texas at Austin)H-Index: 12
#2Kelly R. Reveles (University of Texas at Austin)H-Index: 14
Last. Christopher R. Frei (University of Texas at Austin)H-Index: 29
view all 7 authors...
Background The use of antibiotics is the single most important driver in antibiotic resistance. Nevertheless, antibiotic overuse remains common. Decline in antibiotic prescribing in the United States coincided with the launch of national educational campaigns in the 1990s and other interventions, including the introduction of routine infant immunizations with the pneumococcal conjugate vaccine (PCV-7); however, it is unknown if these trends have been sustained through recent measurements.
154 CitationsSource
#1Colleen R. Kelly (Brown University)H-Index: 29
#2Chioma Ihunnah (Brown University)H-Index: 2
Last. Lawrence J. Brandt (Yeshiva University)H-Index: 10
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Fecal Microbiota Transplant for Treatment of Clostridium difficile Infection in Immunocompromised Patients
429 CitationsSource
Recurrent and refractory Clostridium difficile infection (CDI) is a growing medical concern, with a recent dramatic increase in the number of patients globally [1–4]. In the United States, the incidence of CDI has tripled over the last 15 years [3]. Response to standard antimicrobial therapy with oral vancomycin or metronidazole is suboptimal, with CDI recurring in up to 30% of individuals treated for a first episode. After 2 or more episodes of CDI, the estimated risk for subsequent recurrence ...
322 CitationsSource
#1Sumei Sha (Fourth Military Medical University)H-Index: 10
#2Jie Liang (Fourth Military Medical University)H-Index: 23
Last. Kai Chun Wu (Fourth Military Medical University)H-Index: 14
view all 7 authors...
Summary Background There has been growing interest in the use of faecal microbiota transplantation (FMT) for the treatment of gastrointestinal and nongastrointestinal diseases. Aim To review systematically the reported efficacy and safety of FMT in the management of gastrointestinal and nongastrointestinal disorders in adults and children. Methods The systematic review followed Cochrane and PRISMA recommendations. Available articles were identified using three electronic databases in addition to...
109 CitationsSource
The increasing public interest in fecal microbiota transplant (FMT) raises serious concerns, when the application of this treatment is still in its infancy and long-term safety is not yet established. Indeed, there is evidence that anecdotal reports of success from initial results of uncontrolled studies are encouraging patients to try this line of treatment in the absence of medical direction or supervision. It is important that medical practitioners, the media and the general public are made a...
36 CitationsSource
Cited By6
#1Yuan Gao (NCU: Nanchang University)
#2Qingyao Shang (NCU: Nanchang University)
Last. Tingtao ChenH-Index: 15
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#1Susan E. Hromada (UW: University of Wisconsin-Madison)H-Index: 3
#2Ryan L. ClarkH-Index: 8
Last. Ophelia S. VenturelliH-Index: 11
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Understanding the principles of colonization resistance of the gut microbiome to the pathogen Clostridioides difficile will enable the design of next generation defined bacterial therapeutics. We investigate the ecological principles of community resistance to C. difficile invasion using a diverse synthetic human gut microbiome. Our results show that species richness is a key determinant of C. difficile growth across a wide range of ecological contexts. Using a dynamic computational model, we de...
Last. A. Maya RaH-Index: 1
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Air Susu Ibu (ASI) merupakan sumber nutrisi paling baik karena mengandung berbagai senyawa sehat dan dapat menjaga serta meningkatkan sistem kekebalan tubuh bayi. Terkait peran dan fungsi ASI pada sistem imun, beberapa penelitian tentang mikrobiota usus juga membuktikan peran pentingnya dalam perkembangan sistem imun tersebut. Penelitian ini bertujuan mengkarakterisasi DNA mikrobiota usus bayi yang dilahirkan dengan persalinan normal yang diberi ASI dan Susu Formula (Sufor). Penelitian ini mengg...
1 CitationsSource
#1Jhansi L. Leslie (UM: University of Michigan)H-Index: 13
#2Kimberly C. Vendrov (UM: University of Michigan)H-Index: 8
Last. Vincent B. Young (UM: University of Michigan)H-Index: 74
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ABSTRACT Clostridium (Clostridioides) difficile, a Gram-positive, anaerobic bacterium, is the leading single cause of nosocomial infections in the United States. A major risk factor for Clostridium difficile infection (CDI) is prior exposure to antibiotics, as they increase susceptibility to CDI by altering the membership of the microbial community enabling colonization. The importance of the gut microbiota in providing protection from CDI is underscored by the reported 80 to 90% success rate of...
25 CitationsSource
#1Amin Talebi Bezmin Abadi (TMU: Tarbiat Modares University)H-Index: 16
#2Allison Wren (Kazan: Kazan Federal University)
Last. Albert A. Rizvanov (Kazan: Kazan Federal University)H-Index: 30
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Clostridium difficile is a spore-forming Gram-positive intestinal inhabitant of many asymptomatic and symptomatic individuals. In the past, it was thought to have a commensal relationship with us but recent research has cast doubt on this. C. difficile infection (CDI) is a major public health concern and is associated with a decrease in fecal microbial diversity. In addition, the disrupted gastroduodenal microbial ecosystem by first-line antibiotic therapy is a predisposing factor for bacterial ...