Bioscience Horizons
Papers 133
1 page of 14 pages (133 results)
#1Ekta N. Haria (Drake University)H-Index: 1
#2M. Ann D. N. Perera (Iowa State University)H-Index: 12
Last. David S. Senchina (Drake University)H-Index: 9
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Echinacea supplements may prevent or reduce symptoms of upper respiratory infections by immunomodulation, possibly by altering the cytokine profile. Compared with other species in the genus, the immunomodulatory properties of Echinacea laeviagata are poorly characterized. The purposes of this study were to compare the diversity and quantity of known bioactive compounds from aboveground organs of E. laevigata, and to characterize the in vitro immumodulatory properties of ethanol tinctures produce...
4 CitationsSource
#1Everlyn Kamau (JKUAT: Jomo Kenyatta University of Agriculture and Technology)
#2Steven G. Nyanjom (JKUAT: Jomo Kenyatta University of Agriculture and Technology)H-Index: 7
Last. Joseph Ng‘ang‘a (JKUAT: Jomo Kenyatta University of Agriculture and Technology)
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#1Henna Khalid (SHU: Sheffield Hallam University)H-Index: 3
Targeting tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a mediator of apoptosis (cell death) and death ligand belonging to the TNF superfamily, represents a promising approach in anti-cancer therapy due to its selectivity to target cancer cell populations yet not normal cells. However, resistance to TRAIL is a common occurrence in tumours, limiting the effects of TRAIL to a minority of TRAIL-sensitive tumours. Peptidylarginine deiminase 4 (PAD4) is a Ca2+-dependent enzy...
#1Chris Dowle (Swansea University)H-Index: 1
5 CitationsSource
#1Hannah Rose Warren (University of Bath)
#2Momna Hejmadi (University of Bath)H-Index: 11
Resistance to chemotherapy is a major obstacle in clinical oncology. Hypoxia is a hallmark of solid tumours as a result of poorly structured tumour neovasculature and is known to be a key contributor to cancer malignancy and reduced drug effectiveness. Hypoxia-inducible factor-1 (HIF-1) mediates the hypoxic response, bringing about adaptive responses to the change in microenvironment. This study investigated the effect of 24 h hypoxia on the sensitivity of SH-SY5Y neuroblastoma cells to 5-fluoro...
#1Kris Sales (UEA: University of East Anglia)H-Index: 5
#2Laurie Kerr (UEA: University of East Anglia)H-Index: 3
Last. Jessie Gardner (Norwich University)H-Index: 4
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The niches of epiphytes are widely studied and have been shown to be complex involving interspecific competition, succession and predation. This study is unique in that it applies the niche concept to moss and lichen distributions within Killarney National Park, Kerry, Ireland. We studied 75 trees between three pristine ancient woodlands and measured a range of physical and biological factors to ascertain influences on epiphyte cover. The species of tree was found as the principal determinant in...
11 CitationsSource
#1Justin G.D. Byrne (Ebor: University of York)H-Index: 1
#2Jonathan W. Pitchford (Ebor: University of York)H-Index: 26
Global biodiversity, and its associated ecosystem services, are threatened due to species extinctions. Reintroducing locally extinct species may be a partial solution to this problem. However, the success and possible consequences of any artificial reintroduction will depend on its ecological community, and the reaction of that community to the species' extinction and reintroduction. Mathematical models can offer useful insights by identifying the key features of communities and reintroduced spe...
1 CitationsSource
#1Katie Baker (University of Wolverhampton)H-Index: 1
Type 1 diabetes mellitus (T1DM) is a chronic life-threatening condition whose incidence in the UK has doubled every 20 years since 1945 (Diabetes UK, 2010). Whilst intensive insulin therapy has been shown to reduce the incidence of long-term vascular complications in T1DM patients, it has also been shown to increase the risk of severe hypoglycaemia by 3-fold. Clinical islet transplantation has progressed considerably over the past decade, yet issues regarding the toxic effects of immunosuppressi...
1 CitationsSource
#1Chinelo A. Ezeabara (Nnamdi Azikiwe University)H-Index: 5
#2C. U. Okeke (Nnamdi Azikiwe University)H-Index: 2
#1Grace Macnee (University of Bath)
#2Momna Hejmadi (University of Bath)H-Index: 11
Adaptation to hypoxia is essential to survival in most organisms; disruption of oxygen homeostasis is linked to the pathology of multiple diseases including neurodegeneration, ischaemic stroke and cancer. Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of oxygen depletion and in mediating the response to hypoxia to maintain cellular oxygen homeostasis. This study investigated hypoxia signalling in vivo using a Caenorhabditis elegans HIF-1 mutant model. The chemo...
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Cell biology