Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression

Volume: 22, Issue: 12, Pages: 1701 - 1713
Published: Sep 20, 2016
Abstract
Stressful life events produce a state of vulnerability to depression in some individuals. The mechanisms that contribute to vulnerability to depression remain poorly understood. A rat model of intense stress (social defeat (SD), first hit) produced vulnerability to depression in 40% of animals. Only vulnerable animals developed a depression-like phenotype after a second stressful hit (chronic mild stress). We found that this vulnerability to...
Paper Details
Title
Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression
Published Date
Sep 20, 2016
Volume
22
Issue
12
Pages
1701 - 1713
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