Original paper
Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice
Abstract
Significance Fragile X syndrome is the most common heritable cause of intellectual disability and autism. Elevated protein synthesis is considered a major contributor to the pathophysiology of fragile X. ERK (extracellular signal-regulated kinase) and mTOR (mechanistic target of rapamycin) are key signaling molecules in two prominent pathways that regulate protein synthesis. A major finding of this study is that ERK (but not mTOR) signaling is...
Paper Details
Title
Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice
Published Date
Sep 23, 2016
Volume
113
Issue
41