Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice

Significance Fragile X syndrome is the most common heritable cause of intellectual disability and autism. Elevated protein synthesis is considered a major contributor to the pathophysiology of fragile X. ERK (extracellular signal-regulated kinase) and mTOR (mechanistic target of rapamycin) are key signaling molecules in two prominent pathways that regulate protein synthesis. A major finding of this study is that ERK (but not mTOR) signaling is...