Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress
Abstract
Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis. Previous studies have indicated that endoplasmic reticulum (ER) stress is involved in the cell death process. Therefore, we investigated the effect of the chemical chaperone 4-phenyl butyric acid (PBA) on APAP-induced liver injury in mice. Eight-week-old male C57Bl6/J mice were given a single intraperitoneal (i.p.) injection of APAP (450...
Paper Details
Title
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress
Published Date
Sep 6, 2016
Journal
Volume
52
Issue
5
Pages
611 - 622
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