Concentrado de fibrinógeno: una opción en el manejo de la hemorragia aguda

Published on Jun 23, 2016
Ángel Augusto Pérez-Calatayud3
Estimated H-index: 3
,
Eduardo Daniel Anica-Malagón1
Estimated H-index: 1
+ 2 AuthorsRaúl Carrillo-Esper10
Estimated H-index: 10
Source
Abstract
* Coordinador de la Terapia Intensiva Obstetrica Hospital General de Mexico «Dr. Eduardo Liceaga» Coordinador del Grupo Mexicano para el Estudio de la Medicina Intensiva. ** Anestesiologia, Medicina en el Enfermo en Estado Critico, Diplomado de Medicina Critica en Obstetricia Hospital General de Mexico «Dr. Eduardo Liceaga». *** Ginecologia y Obstetricia, Medicina Materno Fetal, Diplomado en Medicina Critica en Obstetricia Hospital General de Mexico «Dr. Eduardo Liceaga». + Residente de Tercer ano de Medicina de Urgencias Hospital General «Enrique Cabrera». ++ Academia Nacional de Medicina, Academia Mexicana de Cirugia, Jefe de Terapia Hospital General de Mexico «Dr. Eduardo Liceaga», Fundador Grupo Mexicano para el Estudio de la Medicina Intensiva. Vol. 39. Supl. 2 Julio-Septiembre 2016 pp S300-S304
References45
Newest
#1Shintaro Makino (Juntendo University)H-Index: 14
#2Satoru Takeda (Juntendo University)H-Index: 33
Last. Hideaki Masuzaki (Nagasaki University)H-Index: 44
view all 7 authors...
Aim The aim of this study was to provide basic documents applicable to studying the usefulness of administering fibrinogen concentrate to patients with massive post-partum hemorrhage. We investigated the usage of fibrinogen concentrate at training institutions for specialist physicians of the Japan Society of Obstetrics and Gynecology. Material and Methods The subjects were women who required fibrinogen concentrate for hemostasis of post-partum hemorrhage during the period between April 2008 and...
23 CitationsSource
#1Jens Lunde (Copenhagen University Hospital)H-Index: 4
#2Jakob Stensballe (Copenhagen University Hospital)H-Index: 34
Last. Arash Afshari (Copenhagen University Hospital)H-Index: 29
view all 5 authors...
Fibrinogen concentrate as part of treatment protocols increasingly draws attention. Fibrinogen substitution in cases of hypofibrinogenaemia has the potential to reduce bleeding, transfusion requirement and subsequently reduce morbidity and mortality. A systematic search for randomised controlled trials (RCTs) and non-randomised studies investigating fibrinogen concentrate in bleeding patients was conducted up to November 2013. We included 30 studies of 3480 identified (7 RCTs and 23 non-randomis...
50 CitationsSource
#1Jakob Stensballe (Copenhagen University Hospital)H-Index: 34
#2Sisse R. OstrowskiH-Index: 52
Last. Pär I. JohanssonH-Index: 67
view all 3 authors...
Purpose of reviewBleeding in trauma carries a high mortality and is increased in case of coagulopathy. Our understanding of hemostasis and coagulopathy has improved, leading to a change in the protocols for hemostatic monitoring. This review describes the current state of evidence supporting the use
55 CitationsSource
#1Anne Wikkelsø (UCPH: University of Copenhagen)H-Index: 9
#2Jens Lunde (Copenhagen University Hospital)H-Index: 4
Last. Arash AfshariH-Index: 29
view all 7 authors...
Background Hypofibrinogenaemia is associated with increased morbidity and mortality, but the optimal treatment level, the use of preemptive treatment and the preferred source of fibrinogen remain disputed. Fibrinogen concentrate is increasingly used and recommended for bleeding with acquired haemostatic deficiencies in several countries, but evidence is lacking regarding indications, dosing, efficacy and safety. Objectives We assessed the benefits and harms of fibrinogen concentrate compared wit...
87 CitationsSource
Last. Herbert SchöchlH-Index: 38
view all 6 authors...
Introduction Fibrinogen plays a key role in hemostasis and is the first coagulation factor to reach critical levels in massively bleeding trauma patients. Consequently, rapid estimation of plasma fibrinogen (FIB) is essential upon emergency room (ER) admission, but is not part of routine coagulation monitoring in many centers. We investigated the predictive ability of the laboratory parameters hemoglobin (Hb) and base excess (BE) upon admission, as well as the Injury Severity Score (ISS), to est...
63 CitationsSource
#2Arash Afshari (UCPH: University of Copenhagen)H-Index: 29
Last. Piet Wyffels (UGent: Ghent University)H-Index: 7
view all 22 authors...
The aims of severe perioperative bleeding management are three-fold. First, preoperative identification by anamesis and laboratory testing of those patients for whom the perioperative bleeding risk may be increased. Second, implementation of strategies for correcting preoperative anaemia and stabilisation of the macro- and microcirculations in order to optimise the patient’s tolerance to bleeding. Third, targeted procoagulant interventions to reduce the amount of bleeding, morbidity, mortality a...
698 CitationsSource
#1Donat R. Spahn (UZH: University of Zurich)H-Index: 94
#2Bertil BouillonH-Index: 56
Last. Rolf Rossaint (RWTH Aachen University)H-Index: 7
view all 16 authors...
Introduction: Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient. When these recommendations are implemented patient outcomes may be improved. Methods: The multidisciplinary Task Force for Advanced Bleeding Care in Trauma was formed in 2005 with the aim of developing a guideline for the management of bleeding following severe injury. This document represents an updated version of the guideline published by the group in 2007 and updated in 2010....
749 CitationsSource
BACKGROUND: Despite poor evidence and high costs, fibrinogen concentrate (FC) represents one of the most frequently used hemostatic agents in exsanguinating trauma. The aim was to assess whether the administration of FC in severely injured patients was associated with improved outcomes. METHODS: Patients documented in the Trauma Registry of the German Society for Trauma Surgery (primary admissions, Injury Severity Score [ISS] ≥16) who had received FC during initial care between emergency departm...
55 CitationsSource
#1Niels Rahe-MeyerH-Index: 28
#2Cristina Solomon (MHH: Hannover Medical School)H-Index: 9
Last. Maximilian PichlmaierH-Index: 17
view all 9 authors...
BACKGROUND: Fibrinogen is suggested to play an important role in managing major bleeding. However, clinical evidence regarding the effect of fibrinogen concentrate (derived from human plasma) on transfusion is limited. The authors assessed whether fibrinogen concentrate can reduce blood transfusion when given as intraoperative, targeted, first-line hemostatic therapy in bleeding patients undergoing aortic replacement surgery. METHODS: In this single-center, prospective, placebo-controlled, doubl...
217 CitationsSource
#1S AhmedH-Index: 1
#2C HarrityH-Index: 1
Last. B ByrneH-Index: 2
view all 9 authors...
SUMMARYBackground Fibrinogen replacement is critical in major obstetric haemorrhage (MOH). Purified, pasteurised fibrinogen concentrate appears to have benefit over cryoprecipitate in ease of administration and safety but is unlicensed in pregnancy. In July 2009, the Irish Blood Transfusion Service replaced cryoprecipitate with fibrinogen. Objectives To examine the impact of this externally imposed change on blood product use and clinical outcomes in MOH. Methods Women with MOH requiring fibrino...
81 CitationsSource
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The use of fibrinogen concentrate to treat or prevent major bleeding with regard to potential adverse reactions has not been free of controversy. Our objective was to perform a post-authorization safety study to describe the use of Clottafact® (LFB Biomedicaments) fibrinogen concentrate in real-life medical practice in Mexico. This was a prospective, observational study that collected and evaluated information between January 2017 and June 2019 related to suspected serious adverse reactions (SUS...
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