Original paper
Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity
Abstract
Caloric restriction (CR) protects against many cerebral pathological conditions that are associated with excitotoxic damage and calcium overload, although the mechanisms are still poorly understood. Here we show that CR strongly protects against excitotoxic insults in vitro and in vivo in a manner associated with significant changes in mitochondrial function. CR increases electron transport chain activity, enhances antioxidant defenses, and...
Paper Details
Title
Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity
Published Date
Sep 13, 2016
Journal
Volume
16
Issue
1
Pages
73 - 81