Original paper
Ionic immune suppression within the tumour microenvironment limits T cell effector function
Abstract
Tumours progress despite being infiltrated by tumour-specific effector T cells. Tumours contain areas of cellular necrosis, which are associated with poor survival in a variety of cancers. Here, we show that necrosis releases intracellular potassium ions into the extracellular fluid of mouse and human tumours, causing profound suppression of T cell effector function. Elevation of the extracellular potassium concentration ([K+]e) impairs T cell...
Paper Details
Title
Ionic immune suppression within the tumour microenvironment limits T cell effector function
Published Date
Sep 14, 2016
Journal
Volume
537
Issue
7621
Pages
539 - 543
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Notes
History