Drug

Microbiology

Biology

Antibiotics

Computational biology

Pharmacology

Drug response

Medicine

Proceedings of the National Academy of Sciences

Significance We present a mechanism-free formula that predicts effects of multiple drugs at all doses based on measurements of drug pairs at a few doses. The formula bypasses the combinatorial explosion problem by greatly reducing the number of measurements needed to design optimal cocktails for cancer and infection.

Prediction of multidimensional drug dose responses based on measurements of drug pairs