Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice
Abstract
Alzheimer disease (AD) research has mainly focused on neurodegenerative processes associated with the classic neuropathologic markers of senile plaques and neurofibrillary tangles. Additionally, cerebrovascular contributions to dementia are increasingly recognized, particularly from cerebral small vessel disease (SVD). Remarkably, in AD brains, the apolipoprotein E (ApoE) ɛ4 allele shows male excess for cerebral microbleeds (CMBs), a marker of...
Paper Details
Title
Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice
Published Date
Sep 1, 2016
Journal
Volume
39
Issue
9
Pages
625 - 637
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