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Original paper

Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

eLife6.40
Volume: 5
Published: Sep 9, 2016
Abstract
Human DNA2 (hDNA2) contains both a helicase and a nuclease domain within the same polypeptide. The nuclease of hDNA2 is involved in a variety of DNA metabolic processes. Little is known about the role of the hDNA2 helicase. Using bulk and single-molecule approaches, we show that hDNA2 is a processive helicase capable of unwinding kilobases of dsDNA in length. The nuclease activity prevents the engagement of the helicase by competing for the same...
Paper Details
Title
Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases
Published Date
Sep 9, 2016
Journal
Volume
5
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