The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

The long non-coding RNA Morrbid controls myeloid cell lifespan and regulates apoptosis by repressing the adjacent pro-apoptotic Bcl2l11 gene in cis. Neutrophils, eosinophils and 'classical' monocytes are a first line of defense against pathogens, but their actions can also cause inflammatory diseases. It is important that the lifespan of these myeloid cells is regulated in order to minimize deleterious effects. Jorge Henao-Mejia and colleagues...