Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations

Purpose Obesity is an established risk factor for clear cell renal cell carcinoma (RCC); however, some reports suggest that RCC developing in obese patients may be more indolent. We investigated the clinical and biologic effect of body mass index (BMI) on treatment outcomes in patients with metastatic RCC. Methods The impact of BMI (high BMI: ≥ 25 kg/m 2 v low BMI: < 25 kg/m 2 ) on overall survival (OS) and treatment outcome with targeted...