Review paper
Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
Abstract
In this contribution, we review the molecular and physiological barriers to oral delivery of peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro systems with special emphasis on human intestine in Ussing chambers. First, the molecular constraints to peptide absorption are discussed. Then the physiological barriers to peptide delivery are examined. These include the gastric and intestinal environment, the...
Paper Details
Title
Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
Published Date
Aug 4, 2016
Volume
106
Pages
256 - 276