Advanced Drug Delivery Reviews
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#1Anjali Sharma (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 14
#2Nirnath Sah (JHUSOM: Johns Hopkins University School of Medicine)
Last. Rangaramanujam M. Kannan (ICSCI: Kennedy Krieger Institute)H-Index: 50
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Abstract null null Pre-existing conditions at reproductive age, and complications arising during pregnancy can be detrimental to maternal and fetal health. Current therapies to combat obstetric disorders are limited due to the inherent complexity of pregnancy, and can have harmful effects on developing fetus. Emerging research shows intricate signaling between the cells from mother and fetus at maternal-fetal interface, providing unique opportunities for interventions specifically targeted to th...
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#1Koyel Sen (UConn: University of Connecticut)H-Index: 3
#2Tanu Mehta (UConn: University of Connecticut)H-Index: 1
Last. Bodhisattwa Chaudhuri (UConn: University of Connecticut)H-Index: 18
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Abstract null null Pharmaceutical applications of the 3D printing process have recently matured, followed by the FDA approval of Spritam, the first commercial 3D printed dosage form. Due to being a new technology in the conventional dosage formulation field, there is still a dearth of understanding in the 3D printing process regarding the effect of the raw materials on the printed dosage forms and the plausibility of using this technology in dosage development beyond the conventional ways. In th...
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#1Benjamin A. Kuzma (Harvard University)
#2Isaac J. Pence (Harvard University)H-Index: 15
Last. Conor L. Evans (Harvard University)H-Index: 27
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Abstract null null The biodistribution and pharmacokinetics of drugs are vital to the mechanistic understanding of their efficacy. Measuring antimicrobial drug efficacy has been challenging as plasma concentration is used as a surrogate for tissue concentration yet typically does not reflect that at the intended site(s) of action. Utilizing an image-guided approach, it is feasible to accurately quantify the biodistribution and pharmacokinetics within the desired site(s) of action. We outline ima...
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#1Yanfang Feng (Harvard University)H-Index: 2
#2Caroline Coradi Tonon (Harvard University)
Last. Tayyaba Hasan (Harvard University)H-Index: 90
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Antibiotic treatment, the mainstay to control of bacterial infections, is greatly hampered by the global prevalence of multidrug-resistant (MDR) bacteria. Photodynamic therapy (PDT) is effective against MDR infections, but PDT-induced bacterial inactivation is often incomplete, causing the relapse of infections. Combination of PDT and antibiotics is a promising strategy to overcome the limitation of both antibiotic treatment and PDT, exerting increased disinfection efficacy on MDR bacterial path...
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#1S. Staubach (University of Duisburg-Essen)H-Index: 2
#2Fabiola Nardi Bauer (University of Duisburg-Essen)
Last. Bernd Giebel (University of Duisburg-Essen)H-Index: 41
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Extracellular vesicles (EVs) especially of mesenchymal stem/stomal cells (MSCs) are increasingly considered as biotherapeutic agents for a variety of different diseases. For translating them effectively into the clinics, scalable production processes fulfilling good manufacturing practice (GMP) are needed. Like for other biotherapeutic agents, the manufacturing of EV products can be subdivided in the upstream and downstream processing and the subsequent quality control, each of them containing s...
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#1Sam Maher (RCSI: Royal College of Surgeons in Ireland)H-Index: 22
#2David J. Brayden (UCD: University College Dublin)H-Index: 44
Abstract null null The use of chemical permeation enhancers (PEs) is the most widely tested approach to improve oral absorption of low permeability active agents, as represented by peptides. Several hundred PEs increase intestinal permeability in preclinical bioassays, yet few have progressed to clinical testing and, of those, only incremental increases in oral bioavailability (BA) have been observed. Still, average BA values of ∼1% were sufficient for two recent FDA approvals of semaglutide and...
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Abstract null null Ingestible smart pills have the potential to be a powerful clinical tool in the diagnosis and treatment of gastrointestinal disease. Though examples of this technology, such as capsule endoscopy, have been successfully translated from the lab into clinically used products, there are still numerous challenges that need to be overcome. This review gives an overview of the research being done in the area of ingestible smart pills and reports on the technical challenges in this fi...
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#1Yuan dong Zhang (Zunyi Medical College)
#2Man Li (Sichuan University)
Last. Xun Sun (Sichuan University)H-Index: 50
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Infectious diseases continue to inflict a high global disease burden. The consensus is that vaccination is the most effective option against infectious diseases. Oral vaccines have unique advantages in the prevention of global pandemics due to their ease of use, high compliance, low cost, and the ability to induce both systemic and mucosal immune responses. However, challenges of adapting vaccines for oral administration remain significant. Foremost among these is enzymatic and pH-dependent degr...
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#1Maria Luigia Ibba (University of Naples Federico II)H-Index: 1
#2Giuseppe Ciccone (National Research Council)
Last. Paloma H. Giangrande (UI: University of Iowa)H-Index: 38
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Abstract null null Messenger RNAs (mRNAs) present a great potential as therapeutics for the treatment and prevention of a wide range of human pathologies, allowing for protein replacement, vaccination, cancer immunotherapy, and genomic engineering. Despite advances in the design of mRNA-based therapeutics, a key aspect for their widespread translation to clinic is the development of safe and effective delivery strategies. To this end, non-viral delivery systems including peptide-based complexes,...
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#1Michael S. Roberts (UniSA: University of South Australia)H-Index: 93
#2Hanumanth Srikanth Cheruvu (UQ: University of Queensland)H-Index: 1
Last. Jeffrey E. Grice (UQ: University of Queensland)H-Index: 31
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Topical products, widely used to manage skin conditions, have evolved from simple potions to sophisticated delivery systems. Their development has been facilitated by advances in percutaneous absorption and product design based on an increasingly mechanistic understanding of drug-product-skin interactions, associated experiments, and a quality-by-design framework. Topical drug delivery involves drug transport from a product into the skin to a local target site and then clearance by diffusion, me...
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