Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions

Volume: 7, Issue: 1
Published: Jul 25, 2016
Abstract
Claudins are tetraspan transmembrane tight-junction proteins that regulate epithelial barriers. In the distal airspaces of the lung, alveolar epithelial tight junctions are crucial to regulate airspace fluid. Chronic alcohol abuse weakens alveolar tight junctions, priming the lung for acute respiratory distress syndrome, a frequently lethal condition caused by airspace flooding. Here we demonstrate that in response to alcohol, increased...
Paper Details
Title
Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
Published Date
Jul 25, 2016
Volume
7
Issue
1
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