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Original paper

Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

eLife6.40
Volume: 5
Published: Aug 2, 2016
Abstract
Collaboration among the multitude of RNA-binding proteins (RBPs) is ubiquitous, yet our understanding of these key regulatory complexes has been limited to single RBPs. We investigated combinatorial translational regulation by Drosophila Pumilio (Pum) and Nanos (Nos), which control development, fertility, and neuronal functions. Our results show how the specificity of one RBP (Pum) is modulated by cooperative RNA recognition with a second RBP...
Paper Details
Title
Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio
Published Date
Aug 2, 2016
Journal
Volume
5
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