Comparative analysis of the interaction of capecitabine and gefitinib with human serum albumin using 19 F nuclear magnetic resonance-based approach

Monitoring the interaction between drugs and proteins is critical to understanding drug transport and metabolism underlying pharmacodynamics. The binding capacities to human serum albumin of two anticancer drugs, capecitabine and gefitinib, were compared via an approach combining 19F NMR, 1H saturation transfer difference (STD) NMR, circular dichroism and docking simulations. Results showed that the two drugs interaction with human serum albumin...