EUROmediCAT signal detection: a systematic method for identifying potential teratogenic medication

Aims Information about medication safety in pregnancy is inadequate. We aimed to develop a signal detection methodology to routinely identify unusual associations between medications and congenital anomalies using data collected by 15 European congenital anomaly registries. Methods EUROmediCAT database data for 14 950 malformed foetuses/babies with first trimester medication exposures in 1995–2011 were analyzed. The odds of a specific medication...