British Journal of Clinical Pharmacology
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#1Kulchalee Deawjaroen (MU: Mahidol University)H-Index: 1
#2Jutatip Sillabutra (MU: Mahidol University)H-Index: 4
Last. Naeti Suksomboon (MU: Mahidol University)H-Index: 18
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AIMS This study aimed to review systematically all available prediction tools identifying adult hospitalized patients at risk of drug-related problems, and to synthesize the evidence on performance and clinical usefulness. METHODS PubMed, Scopus, Web of Science, Embase, and CINAHL databases were searched for relevant studies. Titles, abstracts and full-text studies were sequentially screened for inclusion by two independent reviewers. The Prediction Model Risk of Bias Assessment Tool (PROBAST) a...
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#1Nerea García‐Beloso (University Hospital Complex Of Vigo)H-Index: 1
#2Irene Altabás-González (University of Vigo)
Last. Jose M. Pego-Reigosa (University of Vigo)H-Index: 1
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Introduction null adalimumab is a biological therapy used to treat different chronic inflammatory diseases. At present, there are an increasing number of adalimumab biosimilars. To assume interchangeability between reference adalimumab and biosimilars as acceptable, there should be evidence about efficacy and safety of this switching. Regulation of this practice falls under the authority of individual European Union member states. null Objectives null to systematically review the evidence on the...
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#2Matthijs D. Kruizinga (LEI: Leiden University)H-Index: 4
Last. Anton H. van Kaam (UvA: University of Amsterdam)H-Index: 21
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INTRODUCTION Therapeutic drug monitoring (TDM) of gentamicin in neonates is recommended for safe and effective dosing and is currently performed by plasma sampling, which is an invasive and painful procedure. In this study, feasibility of a non-invasive gentamicin TDM strategy using saliva was investigated. METHODS This was a multicenter, prospective, observational cohort study including 54 neonates. Any neonate treated with intravenous gentamicin was eligible for the study. Up to 8 saliva sampl...
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#1Andreas Capiau (UGent: Ghent University)H-Index: 2
#2Els Mehuys (UGent: Ghent University)H-Index: 23
Last. Koen Boussery (UGent: Ghent University)H-Index: 23
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AIM Direct oral anticoagulants (DOACs) are increasingly used compared to vitamin K antagonists (VKAs). Guidelines advocate a structured multidisciplinary approach in the management of patients treated with DOACs. The aim of this study was to assess the views and experiences of physicians and pharmacists regarding DOAC use in clinical practice. METHODS An online questionnaire was sent to both primary (general practitioners [GPs], community pharmacists) and secondary healthcare professionals (card...
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#1Aseel S. Abuzour (RMIT: RMIT University)
#2Esnath Magola-Makina (RMIT: RMIT University)
Last. Richard N. Keers (University of Manchester)H-Index: 10
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AIMS To examine the prevalence of potentially hazardous prescribing in the prison setting using prescribing safety indicators (PSIs) and explore their implementation and use in practice. METHODS PSIs were identified and reviewed by the project team following a literature review and a nominal group discussion. Pharmacists at 2 prison sites deployed the PSIs using search protocols within their electronic health record. Prevalence rates and 95% confidence intervals (CIs) were generated for each ind...
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#1Hani Essa (University of Liverpool)H-Index: 3
#2Lauren Walker (University of Liverpool)H-Index: 7
Last. Rajiv Sankaranarayanan (University of Liverpool)H-Index: 1
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Heart failure (HF) with reduced ejection fraction (HFrEF) is a global cause of morbidity and mortality with over 60 million estimated cases worldwide. The burden of HF care is expected to increase with an ageing population as evidenced by the fact that 80% of HF-related hospitalizations occur in those aged above 65. Given the significant morbidity and mortality associated with HFrEF, there is a need for new prognostic therapies that have an impact on morbidity and mortality. In February of 2021,...
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#1Anna K. Tietjen (University of Lübeck)
#2Niklas Kroemer (UHH: University of Hamburg)
Last. Sebastian G. Wicha (UHH: University of Hamburg)H-Index: 13
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AIM This study investigates the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of linezolid in patients infected with multidrug-resistant (MDR) tuberculosis (TB). METHODS A pharmacometric model was developed including 244 timed linezolid concentration samples from 39 patients employing NONMEM® 7.4. The probability of target attainment (PTA, PK/PD target: fAUC/MIC of 119) as well as a region-specific cumulative fraction of response (CFR) were estimated for different dosing regimens. RE...
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#1Sajesh K. Veettil (UofU: University of Utah)H-Index: 10
#2Saranrat SadoyuH-Index: 1
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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AIMS The aim was to perform an umbrella review to summarise the existing evidence on proton-pump inhibitor (PPI) use and adverse outcomes and to grade the certainty of evidence. METHODS Electronic databases were searched up to July 2021 for meta-analyses of cohort studies and/or randomised controlled trials (RCTs). Summary effect sizes from a random-effects model, between-study heterogeneity, 95% prediction interval, small-study effect, excess significance and credibility ceilings were devised t...
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#1Gonjin Song (Ewha Womans University)H-Index: 1
#2Ha Young Yoon (Ewha Womans University)H-Index: 3
Last. Hye Sun Gwak (Ewha Womans University)H-Index: 14
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AIMS: Diverse genetic and/or external factors may induce psoriasis. Drug exposure is 1 such prominent external factor; antihypertensive drugs are reportedly associated with psoriasis, but study results have been inconsistent. In this context, we investigated the associations between antihypertensive drugs and incidence if psoriasis via a systematic literature review and meta-analysis. METHODS: Literature search in databases such as PubMed, Embase and Web of Science was conducted on 8 January 202...
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#1Lauren Walker (University of Liverpool)H-Index: 7
#2Serge Cremers (Columbia University)H-Index: 57
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