PRMT5–PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells
Abstract
Glioblastoma (GBM) represents the most common and aggressive histologic subtype among malignant astrocytoma and is associated with poor outcomes because of heterogeneous tumour cell population including mature non-stem-like cell and immature stem-like cells within the tumour. Thus, it is critical to find new target-specific therapeutic modalities. Protein arginine methyltransferase enzyme 5 (PRMT5) regulates many cellular processes through its...
Paper Details
Title
PRMT5–PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells
Published Date
Jun 13, 2016
Journal
Volume
36
Issue
2
Pages
263 - 274
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