STAR_PAC: A Phase 1B study repurposing ATRA as stromal targeting agent along with gemcitabine and nab¬Paclitaxel for pancreatic cancer

Published on Jun 1, 2016in Pancreatology3.629
· DOI :10.1016/J.PAN.2016.04.019
Hemant M. Kocher41
Estimated H-index: 41
(QMUL: Queen Mary University of London),
David Propper27
Estimated H-index: 27
(QMUL: Queen Mary University of London)
+ 13 AuthorsPeter Sasieni77
Estimated H-index: 77
(QMUL: Queen Mary University of London)
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Pancreatic stellate cells (PSCs) are the major contributor to the aggressive, metastatic, and resilient nature of pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis with a 5-year survival rate of 8%. PSCs constitute more than 50% of the tumor stroma in PDAC, where they induce extensive desmoplasia by secreting abundant extracellular matrix (ECM) proteins. In addition, they establish dynamic crosstalk with cancer cells and other stromal cells, which collectively supports tumor pr...
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Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly chemoresistant malignancy. This chemoresistant phenotype has been historically associated with genetic factors. Major biomedical research efforts were concentrated that resulted in the identification of subtypes characterized by specific genetic lesions and gene expression signatures that suggest important biological differences. However, to date, these distinct differences could not be exploited for therapeutic interventions. Apart fr...
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