SAT0594 Will Anti-Cyclic Citrullinated Peptide Antibody-Positive Connective Tissue Disease Patients Develop Rheumatoid Arthritis? Association with HLA-DRB1 Shared Epitope

Background

Anti-cyclic citrullinated peptide antibody (aCCP) is a widely-used diagnostic marker for rheumatoid arthritis (RA). In spite of its very high specificity, it is also reported that 5 to 10% of non-RA connective tissue disease (CTD) patients are positive for aCCP [1]. It is unknown whether such aCCP-positive non-RA CTD patients may develop RA later. There are few reports that referred long term outcome of aCCP-positive CTD...