A review of chitosan and its derivatives in bone tissue engineering.

Published on Oct 20, 2016in Carbohydrate Polymers7.182
· DOI :10.1016/J.CARBPOL.2016.05.049
R. LogithKumar1
Estimated H-index: 1
(SRM University),
A. KeshavNarayan1
Estimated H-index: 1
(SRM University)
+ 3 AuthorsNagarajan Selvamurugan59
Estimated H-index: 59
(SRM University)
Critical-sized bone defects treated with biomaterials offer an efficient alternative to traditional methods involving surgical reconstruction, allografts, and metal implants. Chitosan, a natural biopolymer is widely studied for bone regeneration applications owing to its tunable chemical and biological properties. However, the potential of chitosan to repair bone defects is limited due to its water insolubility, faster in vivo depolymerization, hemo-incompatibility, and weak antimicrobial property. Functionalization of chitosan structure through various chemical modifications provides a solution to these limitations. In this review, current trends of using chitosan as a composite with other polymers and ceramics, and its modifications such as quaternization, carboxyalkylation, hydroxylation, phosphorylation, sulfation and copolymerization in bone tissue engineering are elaborated.
📖 Papers frequently viewed together
1,031 Citations
1,660 Citations
559 Citations
#1Zhongzheng Zhou (Ocean University of China)H-Index: 11
#2Dong Yan (Ocean University of China)H-Index: 4
Last. Xiguang Chen (Ocean University of China)H-Index: 60
view all 7 authors...
In the present work, N,N,N -trimethyl chitosan (TMC) fibers were synthesized successfully and the resulting quaternized materials were characterized by FTIR. The designed TMC fibers with different degree of quaternization achieved high water absorption capability. In antibacterial activity study, TMC fibers showed high antibacterial activity than chitosan fibers against the gram-negative bacteria Escherichia coli (>63%) and gram-positive bacteria Staphylococcus aureus (>99%). TMC fibers exhibite...
37 CitationsSource
#1Heveline D.M. Follmann (UEM: Universidade Estadual de Maringá)H-Index: 14
#2Alliny F. Naves (USP: University of São Paulo)H-Index: 11
Last. Rafael Silva (UEM: Universidade Estadual de Maringá)H-Index: 23
view all 7 authors...
Heparin and different chitosan derivatives were applied to produce stable electrostatic layer-by-layer assemblies and further used as coating technique to inhibit natural inflammatory response to implants. Heparin was assembled with chitosan and N-methylated chitosan derivatives, namely N,N-dimethyl chitosan (DMC) and N,N,N-trimethyl chitosan (TMC), by dipping method. DMC and TMC (chitosan derivatives) were synthesized and characterized before LbL assembly. Ellipsometry, quartz crystal microbala...
20 CitationsSource
#1Yu Chen (BIT: Beijing Institute of Technology)H-Index: 14
#2Yong Zhang (BIT: Beijing Institute of Technology)H-Index: 1
Last. Yongfa ZhengH-Index: 2
view all 9 authors...
The volume phase transition of a hydrogel initiated by shrinking may result in complex patterns on its surface. Based on this unique property of hydrogel, we have developed a novel solvent precipitation method to prepare a kind of novel superabsorbent polymers with excellent hemostatic properties. A porous carboxymethyl chitosan grafted poly (acrylic acid) (CMCTS-g-PAA) superabsorbent polymer was prepared by precipitating CMCTS-g-PAA hydrogel with ethanol. Its potential application in hemostatic...
51 CitationsSource
#1Viorica Patrulea (UNIL: University of Lausanne)H-Index: 10
#2N. Hirt-Burri (CHUV: University Hospital of Lausanne)H-Index: 1
Last. Gerrit Borchard (UNIL: University of Lausanne)H-Index: 53
view all 7 authors...
Abstract RGD peptide sequences are known to regulate cellular activities by interacting with α 5 β 1 , α v β 5 and α v β 3 integrin, which contributes to the wound healing process. In this study, RGDC peptide was immobilized onto chitosan derivative 1,6-diaminohexane-O-carboxymethyl-N,N,N-trimethyl chitosan (DAH-CMTMC) to display RGDC-promoting adhesion for enhanced wound healing. The efficiency of N-methylation, O-carboxymethylation and spacer grafting was quantitatively and qualitatively analy...
26 CitationsSource
#1Tai-ying Chen (JNU: Jinan University)H-Index: 1
#2Hao-chao Huang (JNU: Jinan University)H-Index: 1
Last. Ning-jian Ao (JNU: Jinan University)H-Index: 1
view all 6 authors...
Tissue engineering scaffolds combining biominerals and natural polymers are prospective candidates for bone repair materials. In this work, biocompatible and antibacterial scaffolds were prepared by blending alginate, hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and oyster shell powder (OSP) by freeze drying. SEM, FTIR, mechanical testing and BET surface area analysis were applied to characterize the prepared scaffolds. The swelling behavior, biomineralization, in vitro biodegradati...
11 CitationsSource
#1Yi-Xing Huang (WMU: Wenzhou Medical College)H-Index: 11
#2Xiaolei Zhang (WMU: Wenzhou Medical College)H-Index: 21
Last. Huazi Xu (WMU: Wenzhou Medical College)H-Index: 34
view all 4 authors...
The aim of the present study was to fabricate an injectable nano-hydroxyapatite (n-HA)/glycol chitosan (G-CS)/hyaluronic acid (HyA) composite hydrogel and investigate its potent application in bone tissue engineering. The resultant composite hydrogel was thoroughly characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffractometry (XRD). The developed composite hydrogels exhibited a porous structure (pore size: 100–350 μm) associated with many n-HA particles and their aggre...
31 CitationsSource
#1Dan Zhu (SZU: Shenzhen University)H-Index: 1
#2Honghao Cheng (SZU: Shenzhen University)H-Index: 1
Last. Shiguo Chen (SZU: Shenzhen University)H-Index: 21
view all 8 authors...
Abstract Chitosan (CS) has been widely recognized as an important biomaterial due to its good antimicrobial activity, biocompatibility and biodegradability. However, CS is insoluble in water in neutral and alkaline aqueous solution due to the linear aggregation of chain molecules and the formation of crystallinity. This is one of the key factors that limit its practical applications. Therefore, improving the solubility of CS in neutral and alkaline aqueous solution is a primary research directio...
75 CitationsSource
#1Chun-Hua Wang (Binzhou University)H-Index: 12
#2Liu Wenshuai (Binzhou University)H-Index: 4
Last. Feng Zhao (Binzhou University)H-Index: 9
view all 7 authors...
Abstract Five water-soluble O -quaternary ammonium salt-chitosans (QAS-CS) bearing N -methyl- N -R- N , N - bis (2-hydroxyethyl) ammonium bromides ( R = -benzyl (chloride, BNQAS-CS), -dodecyl (C12QAS-CS), -tetradecyl (C14QAS-CS), -hexadecyl (C16QAS-CS), -octadecyl (C18QAS-CS)) were prepared, respectively. They were characterized by FTIR, 1 H NMR and elemental analysis. Through chemical modification of O -quaternized chitosans, the water solubility of all QAS-CS was improved distinctly. Their ant...
29 CitationsSource
#1Jun YouH-Index: 9
#2Shuyi XieH-Index: 6
Last. Jinping ZhouH-Index: 53
view all 7 authors...
Quaternized chitosan (QCh) was homogeneously synthesized by reacting chitosan with 3-chloro-2-hydroxypropyltrimethylammonium chloride (CHPTAC) in alkali/urea aqueous solution for the first time. The structure and solution properties of QCh were characterized by using element analysis, FT-IR, 13C NMR, SEC-LLS, rheology, viscometer, and ξ-potential measurements. Subsequently, polyelectrolyte complex (PEC) hydrogels were constructed by in situ polymerization of acrylic acid (AA) monomers in the con...
84 CitationsSource
#1Dongying Hu (NEFU: Northeast Forestry University)H-Index: 6
#2Haixia Wang (NEFU: Northeast Forestry University)H-Index: 3
Last. Lijuan Wang (NEFU: Northeast Forestry University)H-Index: 34
view all 3 authors...
Abstract Antibacterial property of packaging is needed to improve the microbiological safety of foods. The aim of this work was to incorporate various amounts of carboxymethyl cellulose (CMC) into films based on quaternized chitosan (2- N -Hydroxypropyl-3-trimethylammonium chloride chitosan, HTCC) to develop coating for preserving food. The HTCC film and blend films were characterized by Fourier transform infrared spectroscopy, X-ray diffraction measurements, scanning electron microscopy, and th...
84 CitationsSource
Cited By263
#1Miguel R. Matus-Muñoz (Universidad Veracruzana)
#2Rubén Ruiz-Ramos (Universidad Veracruzana)H-Index: 9
Last. C. Mendoza-Barrera (BUAP: Benemérita Universidad Autónoma de Puebla)H-Index: 3
view all 6 authors...
In this work, we fabricated scaffolds for epithelial cell differentiation based on functional fibers. Chitosan, PCL, and PLLA composite scaffolds were electrospun under two controlled atmospheres. ...
The bone repair process, among other physiological mechanisms, occurs in a harmonious manner throughout the body. However, the presence of some deleterious factors such as surgery, trauma or pathology, can interfere with the physiology of bone remodeling. It´s Known that the synergistic antimicrobial action between drugs and biomaterials can help and favor osteogenesis after grafting surgery. Therefore, this study aims to develop chitosan / hydroxyapatite scaffolds with amoxicillin for bone repa...
#1Joseph Rey H. Sta. Agueda (DLSU: De La Salle University)H-Index: 1
#2Qiyi Chen (Case Western Reserve University)H-Index: 14
Last. Rigoberto C. Advincula (Case Western Reserve University)H-Index: 75
view all 15 authors...
Abstract Research on polymer materials for additive manufacturing technology in biomedical applications is as promising as it is numerous, but biocompatibility of printable materials still remains a big challenge. Changes occurring during the 3D-printing processes itself may have adverse effects on the compatibility of the completed print. This prospective will put emphasis on the different additives and processes that can have a direct impact on biocompatibility during and after 3D printing of ...
#1Courtney R Lynch (University of the Witwatersrand)H-Index: 2
#2Pierre P. D. Kondiah (University of the Witwatersrand)H-Index: 14
Last. Yahya E. Choonara (University of the Witwatersrand)H-Index: 37
view all 3 authors...
Tissue engineering is known to encompass multiple aspects of science, medicine and engineering. The development of systems which are able to promote the growth of new cells and tissue components are vital in the treatment of severe tissue injury and damage. This can be done through a variety of different biofabrication strategies including the use of hydrogels, 3D bioprinted scaffolds and nanotechnology. The incorporation of stem cells into these systems and the advantage of this is also discuss...
#1Miao Zhang (Ocean University of China)
#2Xiaoni Qiao (Ocean University of China)
Last. Xia Zhao (Ocean University of China)H-Index: 18
view all 6 authors...
Abstract Moist, breathable and antibacterial microenvironment can promote cell proliferation and migration, which is beneficial to wound healing. Here, we fabricated a novel sodium alginate-chitosan oligosaccharide‑zinc oxide (SA-COS-ZnO) composite hydrogel by spontaneous Schiff base reaction, using aldehydated sodium alginate (SA), chitosan oligosaccharide (COS), and zinc oxide (ZnO) nanoparticles, which can provide a moist and antibacterial environment for wound healing. The porosity and swell...
#1Mengyang Wang (Ocean University of China)H-Index: 2
#2Bi ShichaoH-Index: 1
Last. Xiguang Chen (Ocean University of China)H-Index: 60
view all 8 authors...
Abstract In the present research, nutrient broth (NB) medium was identified to be able to neutralize the antibacterial activity of chitosan and its derivatives. Therefore, an improved test method independent of NB medium was proposed to precisely quantify the antibacterial effectiveness and efficiency of chitosan. The minimum bactericidal concentration (MBC) of chitosan was 60 μg mL−1 against S. aureus and E. coli, and 0.01 % (w/v) chitosan could kill 100 % of bacteria within 3 min. From another...
1 CitationsSource
#1Tingting Zheng (Sichuan University)
#2Pingping Tang (Sichuan University)
Last. Guoying Li (Sichuan University)H-Index: 21
view all 5 authors...
#1Namrata Yadav (IIT: Indian Institute of Technology (BHU) Varanasi)H-Index: 2
#2Pradeep Srivastava (IIT: Indian Institute of Technology (BHU) Varanasi)H-Index: 4
Designing of a suitable ‘cell-material’ construct has enabled the regeneration of bone. It was in accordance with the increasing demand for the repair of defective and/or diseased bone tissue. In this research, the relative behavior of the osteoblast-seeded materials was demonstrated. It enabled the selection of the cell-material system for rabbit bone bioengineering studies. Significant role of polypeptide-polymer-ceramic-cell material in bone tissue engineering was shown. The properties of nat...
#1Parinaz Abdollahiyan (Tabriz University of Medical Sciences)H-Index: 3
#2Fatemeh OroojalianH-Index: 14
Last. Ahad Mokhtarzadeh (Tabriz University of Medical Sciences)H-Index: 32
view all 5 authors...
Abstract The tissue engineering of hard organs and tissues containing cartilage, teeth, and bones is a widely used and rapidly progressing field. One of the main features of hard organs and tissues is the mineralization of their extracellular matrices (ECM) to enable them to withstand pressure and weight. Recently, a variety of printing strategies have been developed to facilitate hard organ and tissue regeneration. Fundamentals in three-dimensional (3D) printing techniques are rapid prototyping...
1 CitationsSource