[Difference of immunogenicity evoking in rabbits after immunization with a low-molecular antigen by various routes].

The present studies were undertaken to clarify the difference of the immunogenicity evoked in rabbits immunized with a low-molecular chemical antigen (TNBS) alone, by four administration routes. Rabbits were divided into four experimental groups: TNBS sc group, i.v. group, im group and ip group (3 times/week, 10 times in total), and immune responses to TNBS were estimated by the assay systems of humoral immunoreactions (HA.PCA.Arthus) and...