Effects of purified zearalenone on selected immunological measurements of blood in post-weaning gilts

Published on Sep 1, 2016in Animal Nutrition4.492
· DOI :10.1016/J.ANINU.2016.04.008
Lijie Yang4
Estimated H-index: 4
(SDAU: Shandong Agricultural University),
Yang Weiren7
Estimated H-index: 7
(SDAU: Shandong Agricultural University)
+ 5 AuthorsZaibin Yang9
Estimated H-index: 9
(SDAU: Shandong Agricultural University)
Sources
Abstract
Abstract Zearalenone (ZEA), an estrogenic mycotoxin, is produced mainly by Fusarium fungi. Previous studies have indicated that acute ZEA exposure induced various damages in different species; however, its transparent hematotoxicity in female piglets at dietary levels of 1.1 to 3.2 mg/kg has not been shown. The present study was conducted to investigate the effects of dietary ZEA (1.1–3.2 mg/kg) on hematology, T lymphocyte subset, immunoglobulin, antibody titer, lymphocyte proliferation rate (LPR), and interleukin-2 (IL-2) in peripheral blood of post-weaning gilts. A total of 20 female piglets (Landrace × Yorkshire × Duroc), weaned at 42 d with an average body weight of 10.36 ± 1.21 kg were used in the study. Female piglets were kept in a temperature controlled room, divided into four treatments, and fed a diet based on corn-soybean meal-fishmeal-whey, with an addition of 0, 1.1, 2.0, or 3.2 mg/kg purified ZEA for 18 d ad libitum . Feed intake and refusal were measured daily and individual pigs were weighed weekly. Blood and serum samples were collected for selected immunological measurements. Female piglets fed different levels of dietary ZEA grew similarly with no difference in feed intake. Hematological values including leukocytes, platelets, lymphocytes, hematocrit, and mean corpuscular hemoglobin (MCH) decreased linearly ( P + CD8 + , CD4 + , and CD4 + /CD8 + in comparison to the control ( P + was significantly increased ( P  = 0.026) in the gilts which were fed the diet containing 3.2 mg/kg ZEA. Serum immunoglobulin G (IgG) and the antibody titer on d 18 were reduced linearly as dietary ZEA levels increased ( P P P
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