N-of-1 trials are a tapestry of heterogeneity

Objectives To summarize the methods of design, analysis, and meta-analysis used in N-of-1 trials. Study Design and Setting Electronic search for English language articles published from 1950 to 2013. N-of-1 trials were selected if they followed an ABAB design and if they assessed a health intervention for a medical condition. Elements of design, analysis, and meta-analysis were extracted. Results We included 100 reports representing 1,995...