[Advances in study on the pharmacological effects of active components of Chinese herbs on Alzheimer's disease].

Published on May 1, 2004in China journal of Chinese materia medica
Lei Wu1
Estimated H-index: 1
,
Shuyi Cheng2
Estimated H-index: 2
(GU: Guangzhou University)
+ 1 AuthorsYunbo Chen3
Estimated H-index: 3
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Abstract
Based on the pharmacological research of Chinese herbs on AD and some famous hypothesis on AD, such as disfunction of nervous transmitter metabolism, apoptosis, inflammation etc, we consulted and analyzed relevant papers. We found the effective mechanism of Ginsenoside, Osthol, Rhodosin, and (-)Clausenamide were related to many pathological channels of AD, and Ginsenoside had effect on many pathological channels. The results have provided some clues for selecting effective herbs on AD.
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This paper reviews the latest understanding of biological and pharmacological properties of osthole (7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one), a natural product found in several medicinal plants such as Cnidium monnieri and Angelica pubescens. In vitro and in vivo experimental results have revealed that osthole demonstrates multiple pharmacological actions including neuroprotective, osteogenic, immunomodulatory, anticancer, hepatoprotective, cardiovascular protective, and antimicr...
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Alzheimer's disease (AD) is a severe condition in aging countries. The currently used drugs including donepezil, rivastigmine, galantamine, and memantine are effective in managing the symptoms. However, they are hardly capable of preventing, halting, or reversing the disease. In the long history of development of traditional Chinese medicine, much experience has accumulated and is summarized in treatment of diseases that correspond to the concept of AD. In recent years, exploration of natural ac...
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Abstract Background Aggregation of β-amyloid peptide (Aβ), excitatory intoxication, oxidation injury and inflammation reaction are generally regarded as the main pathogenesis for Alzheimer disease (AD). (–) clausenamide is characterized by promoting intelligent development, resisting oxidation, cleaning free radicals, resisting Aβ neurotoxicity and nerve cell apoptosis, inhibiting over phosphorylation of tau protein, and improving central cholinergic system. However, whether (–) clausenamide has...
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