Yunbo Chen
Guangzhou University
Internal medicineSynapseEndocrinologyCREBLipofuscinIn vitroImmunologyAutophagyLong-term potentiationNeuroprotectionSuperoxide dismutaseGinsenosideOstholDiseasePeptideHippocampusChinese herbsActive componentsNeuronal apoptosisPharmacological researchCortex (botany)Ca2+/calmodulin-dependent protein kinaseSignal transductionMedicineBiologyMechanism (biology)Gap-43 proteinCell biologyPharmacology
Publications 3
#1Yunbo Chen (GU: Guangzhou University)H-Index: 3
#2Gang Wei (GU: Guangzhou University)H-Index: 3
Last. Dong-Feng Chen (GU: Guangzhou University)H-Index: 6
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Abstract β-Asarone is an active component of the Acori graminei rhizome that is a traditional Chinese medicine clinically used in treating dementia in China. However, the cognitive effect of β-asarone and its mechanism has remained elusive. Here, we used asenescence-accelerated prone 8 (SAMP8) mice, which mimic many of the salient features of Alzheimer׳s disease (AD), to further investigate whether modulation of the ROCK signaling pathway and/or autophagy, synaptic loss is involved in the effect...
24 CitationsSource
#1Gang Wei (GU: Guangzhou University)H-Index: 3
#2Yunbo Chen (GU: Guangzhou University)H-Index: 3
Last. Hui Nie (GU: Guangzhou University)H-Index: 2
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Abstract β-Asarone, an active component of the Acori graminei rhizome that has been used as traditional Chinese herb, has been reported to be capable of inhibiting neuronal apoptosis. However, the signaling mechanism underlying the inhibitory effect of β-asarone has remained elusive. This study was aimed to investigate whether the CaMKII signaling pathway is involved in the β-asarone mediated neuroprotection. Using PC12 cells and primary cultures of cortical neurons treated with amyloid-β (Aβ)(1...
38 CitationsSource
#1Lei WuH-Index: 1
#2Shuyi Cheng (GU: Guangzhou University)H-Index: 2
Last. Yunbo ChenH-Index: 3
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Based on the pharmacological research of Chinese herbs on AD and some famous hypothesis on AD, such as disfunction of nervous transmitter metabolism, apoptosis, inflammation etc, we consulted and analyzed relevant papers. We found the effective mechanism of Ginsenoside, Osthol, Rhodosin, and (-)Clausenamide were related to many pathological channels of AD, and Ginsenoside had effect on many pathological channels. The results have provided some clues for selecting effective herbs on AD.
4 Citations