Progranulin Plays a Central Role in Host Defense during Sepsis by Promoting Macrophage Recruitment

Progranulin, a widely expressed protein, has multiple physiological functions. The functional role of progranulin in the host response to sepsis remains unknown.To assess the role of progranulin in the host response to sepsis.Effects of progranulin on host response to sepsis were determined.Progranulin concentrations were significantly elevated in adult (n = 74) and pediatric (n = 26) patients with sepsis relative to corresponding healthy adult...